9 November 2021 |
| 18h00 | London Polonia (ENG) | Cancelled | Orion Stars Doetinchem (NED) |
| 18h00 | Tartu BB (EST) | 1 - 3 (21-25, 18-25, 25-20, 23-25) | Zenit Kazan (RUS) |
| 19h00 | Shakhtar Soligorsk (BLR) | 0 - 3 (20-25, 22-25, 21-25) | SWD Powervolleys Düren (GER) |
10 November 2021 |
| 17h00 | CS Arcada Galati (ROM) | 3 - 1 (25-19, 25-17, 22-25, 25-21) | VK Lvi Praha (CZE) |
| 17h00 | Zenit Kazan (RUS) | 3 - 0 (25-21, 25-17, 25-19) | Tartu BB (EST) |
| 17h30 | VaLePa Sastamala (FIN) | 0 - 3 (18-25, 19-25, 23-25) | Modena Volley (ITA) |
| 18h00 | OK Budvanska Rivijera Budva (MNE) | 2 - 3 (20-25, 25-21, 25-21, 22-25, 7-15) | Volley Haasrode Leuven (BEL) |
| 19h00 | UVC Holding Graz (AUT) | 1 - 3 (17-25, 19-25, 31-29, 22-25) | CS Dinamo Bucharest Volley (ROM) |
| 19h00 | SVG Luneburg (GER) | 3 - 0 (25-20, 25-21, 25-22) | Ribnica Kraljevo (SCG) |
| 19h00 | SWD Powervolleys Düren (GER) | 3 - 0 (25-16, 25-21, 25-23) | Shakhtar Soligorsk (BLR) |
| 19h00 | Volley Amriswil (SWI) | 3 - 1 (19-25, 25-21, 25-17, 25-21) | Chênois Genève (SWI) |
| 19h30 | Draisma Dynamo Apeldoorn (NED) | 1 - 3 (22-25, 17-25, 25-19, 16-25) | Tours VB (FRA) |
| 20h15 | Rieker UJS Komarno (SVK) | 1 - 3 (25-23, 20-25, 13-25, 10-25) | Arkas Spor Izmir (TÜR) |
| 20h30 | CV Guaguas Las Palmas (SPA) | 3 - 0 (25-20, 25-22, 25-22) | Calcit Kamnik (SLO) |
11 November 2021 |
| 19h00 | HAOK Mladost Zagreb (CRO) | 3 - 0 (26-24, 25-23, 25-12) | SK Ústí nad Labem (CZE) |
16 November 2021 |
| 18h00 | OK Mladost Brcko (BIH) | 0 - 3 (17-25, 23-25, 14-25) | PGE Skra Belchatow (POL) |
17 November 2021 |
| 17h00 | Arkas Spor Izmir (TÜR) | 3 - 0 (25-20, 25-16, 25-20) | Rieker UJS Komarno (SVK) |
| 18h00 | SK Ústí nad Labem (CZE) | 1 - 3 (25-21, 21-25, 23-25, 21-25) | HAOK Mladost Zagreb (CRO) |
| 18h00 | CS Dinamo Bucharest Volley (ROM) | 3 - 1 (20-25, 25-12, 25-23, 25-21) | UVC Holding Graz (AUT) |
| 19h00 | VK Lvi Praha (CZE) | 3 - 2 (23-25, 25-18, 17-25, 25-19, 15-12) | CS Arcada Galati (ROM) |
| 19h00 | Ribnica Kraljevo (SCG) | 3 - 1 (25-18, 25-22, 21-25, 25-18) | SVG Luneburg (GER) |
| 19h00 | Chênois Genève (SWI) | 3 - 0 (25-23, 25-23, 25-18) | Volley Amriswil (SWI) |
| 20h00 | Calcit Kamnik (SLO) | 1 - 3 (24-26, 25-19, 21-25, 21-25) | CV Guaguas Las Palmas (SPA) |
| 20h00 | Orion Stars Doetinchem (NED) | 3 - 2 (21-25, 25-19, 25-22, 21-25, 15-12) | London Polonia (ENG) |
| 20h00 | Tours VB (FRA) | 3 - 0 (25-14, 25-14, 25-17) | Draisma Dynamo Apeldoorn (NED) |
| 20h30 | Volley Haasrode Leuven (BEL) | 3 - 1 (25-8, 17-25, 25-22, 25-19) | OK Budvanska Rivijera Budva (MNE) |
| 20h30 | Modena Volley (ITA) | 3 - 0 (25-21, 25-14, 25-14) | VaLePa Sastamala (FIN) |
18 November 2021 |
| 18h00 | PGE Skra Belchatow (POL) | 3 - 0 (25-20, 25-8, 25-14) | OK Mladost Brcko (BIH) |
30 November 2021 |
| 20h00 | Chênois Genève (SWI) | 2 - 3 (23-25, 25-18, 19-25, 25-19, 14-16) | Neftohimic 2010 Burgas (BUL) |
| 20h30 | Modena Volley (ITA) | 3 - 1 (25-15, 25-17, 20-25, 25-21) | SCM Zalau (ROM) |
1 December 2021 |
| 16h00 | CS Dinamo Bucharest Volley (ROM) | 2 - 3 (26-28, 25-19, 21-25, 25-21, 11-15) | United Volleys Rhein-Main (GER) |
| 17h00 | VK Jihostroj Ceske Budejovice (CZE) | 2 - 3 (23-25, 25-19, 25-21, 22-25, 20-22) | Kuzbass Kumerovo (RUS) |
| 17h00 | Arkas Spor Izmir (TÜR) | 3 - 2 (25-21, 25-22, 21-25, 17-25, 15-7) | Spor Toto SK Ankara (TÜR) |
| 18h00 | SCM Zalau (ROM) | 0 - 3 (13-25, 14-25, 15-25) | Modena Volley (ITA) |
| 18h00 | CS Arcada Galati (ROM) | 3 - 0 (25-18, 25-23, 31-29) | Chaumont 52 Haute-Marne (FRA) |
| 18h00 | PGE Skra Belchatow (POL) | 3 - 0 (25-15, 25-20, 25-21) | VK Dukla Liberec (CZE) |
| 19h00 | Ribnica Kraljevo (SCG) | 1 - 3 (19-25, 25-20, 16-25, 18-25) | CEZ Karlovarsko Karlovy Vary (CZE) |
| 19h30 | HAOK Mladost Zagreb (CRO) | 1 - 3 (16-25, 25-18, 24-26, 22-25) | Vero Volley Monza (ITA) |
| 20h00 | Tours VB (FRA) | 3 - 1 (25-15, 19-25, 25-17, 25-15) | Lycurgus Groningen (NED) |
| 20h00 | Montpellier HSC Volley-Ball (FRA) | 3 - 0 (25-20, 25-22, 25-14) | Olympiacos Piraeus (GRE) |
| 20h30 | CV Guaguas Las Palmas (SPA) | 3 - 1 (19-25, 25-17, 25-16, 25-15) | Volley Menen (BEL) |
| 20h30 | Volley Haasrode Leuven (BEL) | 3 - 0 (25-21, 28-26, 25-19) | Foinikas Syros (GRE) |
2 December 2021 |
| 20h00 | Orion Stars Doetinchem (NED) | 3 - 0 (25-16, 25-18, 25-20) | TSV Jona (SWI) |
7 December 2021 |
| 17h00 | Neftohimic 2010 Burgas (BUL) | 3 - 1 (17-25, 29-27, 25-21, 25-20) | Chênois Genève (SWI) |
| 19h00 | SWD Powervolleys Düren (GER) | 2 - 3 (19-25, 26-24, 25-23, 23-25, 14-16) | Galatasaray SK Istanbul (TÜR) |
| 19h00 | Olympiacos Piraeus (GRE) | 2 - 3 (19-25, 20-25, 25-23, 26-24, 15-17) | Montpellier HSC Volley-Ball (FRA) |
8 December 2021 |
| 15h00 | Spor Toto SK Ankara (TÜR) | 3 - 1 (25-19, 25-20, 23-25, 25-20) | Arkas Spor Izmir (TÜR) |
| 17h00 | SK Aich/Dob (AUT) | 0 - 3 (12-25, 18-25, 19-25) | Zenit Kazan (RUS) |
| 17h00 | Foinikas Syros (GRE) | 3 - 1 (21-25, 25-17, 25-15, 25-17) | Volley Haasrode Leuven (BEL) |
| 18h00 | CEZ Karlovarsko Karlovy Vary (CZE) | 3 - 1 (20-25, 28-26, 25-18, 25-17) | Ribnica Kraljevo (SCG) |
| 19h00 | United Volleys Rhein-Main (GER) | 3 - 2 (23-25, 25-13, 24-26, 25-23, 15-9) | CS Dinamo Bucharest Volley (ROM) |
| 19h00 | Galatasaray SK Istanbul (TÜR) | 3 - 0 (25-17, 25-19, 25-23) | SWD Powervolleys Düren (GER) |
| 20h00 | Volley Menen (BEL) | 0 - 3 (22-25, 20-25, 19-25) | CV Guaguas Las Palmas (SPA) |
| 20h00 | Lycurgus Groningen (NED) | 0 - 3 (11-25, 21-25, 22-25) | Tours VB (FRA) |
| 20h00 | Chaumont 52 Haute-Marne (FRA) | 3 - 2 (25-20, 22-25, 20-25, 25-23, 17-15) | CS Arcada Galati (ROM) |
9 December 2021 |
| 13h00 | Kuzbass Kumerovo (RUS) | 3 - 1 (25-21, 19-25, 25-14, 25-21) | VK Jihostroj Ceske Budejovice (CZE) |
| 17h00 | Zenit Kazan (RUS) | 3 - 0 (25-17, 25-23, 25-12) | SK Aich/Dob (AUT) |
| 18h00 | VK Dukla Liberec (CZE) | 1 - 3 (20-25, 17-25, 25-23, 23-25) | PGE Skra Belchatow (POL) |
| 19h00 | Vero Volley Monza (ITA) | 3 - 1 (23-25, 25-14, 25-15, 25-20) | HAOK Mladost Zagreb (CRO) |
16 December 2021 |
| 20h00 | TSV Jona (SWI) | 1 - 3 (23-25, 18-25, 25-23, 11-25) | Orion Stars Doetinchem (NED) |
11 January 2022 |
| 18h00 | Neftohimic 2010 Burgas (BUL) | 2 - 3 (22-25, 26-24, 24-26, 25-21, 12-15) | PGE Skra Belchatow (POL) |
12 January 2022 |
| 17h00 | Spor Toto SK Ankara (TÜR) | 0 - 3 (12-25, 16-25, 18-25) | Vero Volley Monza (ITA) |
| 17h00 | Zenit Kazan (RUS) | 3 - 0 (25-12, 25-19, 25-14) | Orion Stars Doetinchem (NED) |
| 18h00 | CEZ Karlovarsko Karlovy Vary (CZE) | 3 - 0 (25-23, 25-18, 25-16) | Galatasaray SK Istanbul (TÜR) |
| 20h00 | Montpellier HSC Volley-Ball (FRA) | 0 - 3 (forfeit) | Kuzbass Kumerovo (RUS) |
| 20h00 | Tours VB (FRA) | 3 - 1 (22-25, 25-23, 27-25, 25-19) | Modena Volley (ITA) |
| 20h30 | Volley Haasrode Leuven (BEL) | 0 - 3 (16-25, 22-25, 21-25) | CV Guaguas Las Palmas (SPA) |
18 January 2022 |
| 17h00 | United Volleys Rhein-Main (GER) | 0 - 3 (24-26, 13-25, 17-25) | CS Arcada Galati (ROM) |
| 18h00 | PGE Skra Belchatow (POL) | 3 - 1 (25-10, 24-26, 25-15, 25-14) | Neftohimic 2010 Burgas (BUL) |
19 January 2022 |
| 15h00 | Kuzbass Kumerovo (RUS) | 3 - 0 (forfeit) | Montpellier HSC Volley-Ball (FRA) |
| 19h00 | Vero Volley Monza (ITA) | 3 - 0 (25-18, 25-18, 25-20) | Spor Toto SK Ankara (TÜR) |
| 20h30 | Modena Volley (ITA) | 3 - 2 (25-17, 24-26, 33-35, 25-19, 15-13) | Tours VB (FRA) |
20 January 2022 |
| 17h00 | Galatasaray SK Istanbul (TÜR) | 1 - 3 (25-17, 17-25, 18-25, 22-25) | CEZ Karlovarsko Karlovy Vary (CZE) |
| 17h00 | CS Arcada Galati (ROM) | 3 - 2 (25-20, 27-29, 25-27, 27-25, 15-11) | United Volleys Rhein-Main (GER) |
| 20h00 | Orion Stars Doetinchem (NED) | 0 - 3 (17-25, 12-25, 17-25) | Zenit Kazan (RUS) |
26 January 2022 |
| 20h30 | CV Guaguas Las Palmas (SPA) | 3 - 0 (27-25, 25-21, 25-20) | Volley Haasrode Leuven (BEL) |
1 February 2022 |
| 18h00 | PGE Skra Belchatow (POL) | 3 - 2 (25-21, 26-24, 19-25, 21-25, 15-13) | CS Arcada Galati (ROM) |
2 February 2022 |
| 20h00 | Tours VB (FRA) | 3 - 0 (25-22, 27-25, 25-22) | CEZ Karlovarsko Karlovy Vary (CZE) |
| 20h30 | CV Guaguas Las Palmas (SPA) | 0 - 3 (15-25, 23-25, 23-25) | Vero Volley Monza (ITA) |
8 February 2022 |
| 17h00 | CS Arcada Galati (ROM) | 1 - 3 (21-25, 25-19, 19-25, 23-25) | PGE Skra Belchatow (POL) |
9 February 2022 |
| 17h00 | Zenit Kazan (RUS) | 3 - 0 (26-24, 25-17, 25-17) | Kuzbass Kumerovo (RUS) |
| 19h00 | Vero Volley Monza (ITA) | 3 - 1 (25-17, 25-12, 24-26, 25-19) | CV Guaguas Las Palmas (SPA) |
10 February 2022 |
| 17h00 | Kuzbass Kumerovo (RUS) | 1 - 3 (18-25, 13-25, 25-22, 14-25) | Zenit Kazan (RUS) |
| 17h00 | CEZ Karlovarsko Karlovy Vary (CZE) | 1 - 3 (28-30, 23-25, 25-21, 26-28) | Tours VB (FRA) |