16 November 2021 |
| 16h00 | Minchanka Minsk (BLR) | 2 - 3
(21-25, 17-25, 25-16, 25-21, 10-15) |  Volero Le Cannet (FRA) |
| 18h00 | FC Porto Voleibol (POR) | 3 - 0
(25-21, 25-18, 25-17) |  Olympiacos Piraeus (GRE) |
| 18h00 | LKS Lodz (POL) | 3 - 1
(25-23, 25-15, 23-25, 25-19) |  MBH Bekescsaba (HUN) |
| 19h00 | ZOK Jedinstvo Brcko (BIH) | 1 - 3
(23-25, 23-25, 25-18, 21-25) |  VK UP Olomouc (CZE) |
| 19h30 | HAOK Mladost Zagreb (CRO) | 3 - 0
(25-21, 25-17, 25-12) |  Banja Luka Volley (BIH) |
17 November 2021 |
| 16h00 | PVK Olymp Praha (CZE) | 0 - 3
(24-26, 14-25, 16-25) |  Volley Düdingen (SWI) |
| 17h00 | Calcit Volleyball Kamnik (SLO) | 3 - 2
(25-20, 25-27, 25-22, 23-25, 15-10) |  Viteos Neuchâtel UC (SWI) |
| 18h00 | Vasas Obuda Budapest (HUN) | 1 - 3
(15-25, 23-25, 25-17, 19-25) |  CS Volei Alba Blaj (ROM) |
| 18h00 | AO Thiras Santorini (GRE) | 3 - 0
(25-23, 25-20, 25-16) |  VC Oudegem (BEL) |
| 19h00 | OK Zeleznicar Lajkovac (SCG) | 0 - 3
(26-28, 17-25, 17-25) |  Eczacibasi Istanbul (TÜR) |
| 19h00 | Proton Volleyball Club Balakovo (RUS) | 1 - 3
(24-26, 18-25, 25-23, 14-25) |  Uralochka NTMK Ekaterinburg (RUS) |
| 19h00 | CV Las Palmas (SPA) | 3 - 1
(25-14, 25-19, 19-25, 25-11) |  OTP Banka Branik Maribor (SLO) |
| 19h00 | SSC Palmberg Schwerin (GER) | 3 - 1
(25-10, 22-25, 27-25, 25-14) |  Neptunes de Nantes VB (FRA) |
| 19h30 | Asterix Avo Beveren (BEL) | 0 - 3
(22-25, 15-25, 19-25) |  AC PAOK Thessaloniki (GRE) |
| 20h00 | VDK Gent Dames (BEL) | 1 - 3
(18-25, 22-25, 25-21, 19-25) |  Busto Arsizio (ITA) |
23 November 2021 |
| 14h00 | Uralochka NTMK Ekaterinburg (RUS) | 3 - 2
(25-22, 25-19, 22-25, 22-25, 15-10) | Proton Volleyball Club Balakovo (RUS) |
| 19h30 | Neptunes de Nantes VB (FRA) | 2 - 3
(14-25, 22-25, 25-23, 26-24, 13-15) | SSC Palmberg Schwerin (GER) |
| 20h00 | Volley Düdingen (SWI) | 3 - 1
(25-23, 23-25, 25-19, 25-21) | PVK Olymp Praha (CZE) |
24 November 2021 |
| 16h00 | Eczacibasi Istanbul (TÜR) | 3 - 0
(25-16, 25-21, 25-13) | OK Zeleznicar Lajkovac (SCG) |
| 17h00 | CS Volei Alba Blaj (ROM) | 3 - 0
(25-19, 25-18, 25-21) | Vasas Obuda Budapest (HUN) |
| 17h00 | VK UP Olomouc (CZE) | 3 - 0
(25-20, 25-19, 25-18) | ZOK Jedinstvo Brcko (BIH) |
| 17h00 | AC PAOK Thessaloniki (GRE) | 3 - 2
(16-25, 14-25, 25-16, 25-18, 16-14) | Asterix Avo Beveren (BEL) |
| 18h00 | MBH Bekescsaba (HUN) | 1 - 3
(25-16, 23-25, 18-25, 25-27) | LKS Lodz (POL) |
| 18h00 | Olympiacos Piraeus (GRE) | 3 - 2
(25-14, 22-25, 25-19, 22-25, 21-19) | FC Porto Voleibol (POR) |
| 18h00 | OTP Banka Branik Maribor (SLO) | 3 - 2
(25-21, 17-25, 25-27, 25-15, 22-20) | CV Las Palmas (SPA) |
| 20h15 | Banja Luka Volley (BIH) | 0 - 3
(16-25, 11-25, 18-25) | HAOK Mladost Zagreb (CRO) |
| 20h30 | Busto Arsizio (ITA) | 3 - 0
(25-16, 25-14, 25-17) | VDK Gent Dames (BEL) |
25 November 2021 |
| 20h00 | Viteos Neuchâtel UC (SWI) | 1 - 3
(17-25, 25-21, 21-25, 21-25) | Calcit Volleyball Kamnik (SLO) |
| 20h00 | Volero Le Cannet (FRA) | 3 - 1
(28-26, 26-28, 25-17, 28-26) | Minchanka Minsk (BLR) |
| 20h00 | VC Oudegem (BEL) | 3 - 0
(25-0, 25-0, 25-0) | AO Thiras Santorini (GRE) |
7 December 2021 |
| 13h00 | FC Porto Voleibol (POR) | 0 - 3
(19-25, 12-25, 24-26) | SSC Palmberg Schwerin (GER) |
| 19h00 | HAOK Mladost Zagreb (CRO) | 3 - 0 | Volley Düdingen (SWI) |
| 20h00 | Volero Le Cannet (FRA) | 3 - 0
(25-20, 30-28, 25-20) | VK UP Olomouc (CZE) |
8 December 2021 |
| 18h00 | AC PAOK Thessaloniki (GRE) | 1 - 3
(22-25, 25-22, 18-25, 24-26) | CS Volei Alba Blaj (ROM) |
| 20h00 | Calcit Volleyball Kamnik (SLO) | 0 - 3
(23-25, 17-25, 15-25) | Eczacibasi Istanbul (TÜR) |
| 20h30 | Busto Arsizio (ITA) | 3 - 0
(29-27, 25-19, 25-23) |  MTV Stuttgart (GER) |
14 December 2021 |
| 14h00 | Uralochka NTMK Ekaterinburg (RUS) | 3 - 0
(25-16, 25-15, 25-16) | VC Oudegem (BEL) |
| 18h00 | CV Las Palmas (SPA) | 0 - 3
(14-25, 19-25, 16-25) | LKS Lodz (POL) |
| 18h00 | Volley Düdingen (SWI) | 0 - 3 | HAOK Mladost Zagreb (CRO) |
| 18h00 | CS Volei Alba Blaj (ROM) | 3 - 0
(25-11, 25-20, 25-19) | AC PAOK Thessaloniki (GRE) |
| 19h00 | SSC Palmberg Schwerin (GER) | 3 - 1
(26-24, 23-25, 25-16, 25-19) | FC Porto Voleibol (POR) |
15 December 2021 |
| 14h00 | VC Oudegem (BEL) | 0 - 3
(20-25, 10-25, 20-25) | Uralochka NTMK Ekaterinburg (RUS) |
| 18h00 | VK UP Olomouc (CZE) | 0 - 3
(21-25, 20-25, 18-25) | Volero Le Cannet (FRA) |
| 18h00 | LKS Lodz (POL) | 3 - 0
(25-23, 25-17, 25-23) | CV Las Palmas (SPA) |
| 19h00 | MTV Stuttgart (GER) | 3 - 1
(25-19, 25-18, 21-25, 25-19) | Busto Arsizio (ITA) |
16 December 2021 |
| 16h00 | Eczacibasi Istanbul (TÜR) | 3 - 0
(25-19, 25-17, 25-23) | Calcit Volleyball Kamnik (SLO) |
25 January 2022 |
| 16h00 | Uralochka NTMK Ekaterinburg (RUS) | 0 - 3
(19-25, 19-25, 21-25) | Eczacibasi Istanbul (TÜR) |
| 18h00 | CS Volei Alba Blaj (ROM) | 3 - 0
(25-19, 25-13, 25-15) | Volero Le Cannet (FRA) |
26 January 2022 |
| 16h00 | Eczacibasi Istanbul (TÜR) | 2 - 3
(25-17, 24-26, 31-29, 19-25, 6-15) | Uralochka NTMK Ekaterinburg (RUS) |
| 18h00 | LKS Lodz (POL) | 2 - 3
(29-31, 21-25, 25-14, 25-17, 8-15) | HAOK Mladost Zagreb (CRO) |
1 February 2022 |
| 17h00 | HAOK Mladost Zagreb (CRO) | 2 - 3
(29-27, 21-25, 14-25, 25-20, 9-15) | LKS Lodz (POL) |
3 February 2022 |
| 19h00 | SSC Palmberg Schwerin (GER) | 0 - 3 | MTV Stuttgart (GER) |
9 February 2022 |
| 19h00 | MTV Stuttgart (GER) | 3 - 1
(25-19, 25-12, 21-25, 25-21) | SSC Palmberg Schwerin (GER) |
15 February 2022 |
| 20h00 | Volero Le Cannet (FRA) | 2 - 3
(25-27, 16-25, 25-22, 25-17, 12-15) | CS Volei Alba Blaj (ROM) |
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