France - 21 September 2021 - 19 December 2021
First Round
Round of 16
Quarter-Finals
Semi-Finals
Final
Detail of the results
Statistics
- General statistics
- Various statistics
Wins
| 1 | Nantes HBC | 4 |
| 2 | Chambéry Savoie Mt-. | 3 |
| 3 | Cesson Rennes Métro. | 1 |
| 4 | FENIX Toulouse HB | 1 |
| 5 | Istres Provence HB | 1 |
| 6 | Montpellier HB | 1 |
Drawn matches
| 1 | Cesson Rennes Métro. | 0 |
| 2 | Chambéry Savoie Mt-. | 0 |
| 3 | Chartres Métropole . | 0 |
| 4 | Dunkerque HB Grand Littora. | 0 |
| 5 | FENIX Toulouse HB | 0 |
| 6 | Istres Provence HB | 0 |
Losses
| 1 | Cesson Rennes Métro. | 1 |
| 2 | Chambéry Savoie Mt-. | 1 |
| 3 | Chartres Métropole . | 1 |
| 4 | Dunkerque HB Grand Littora. | 1 |
| 5 | FENIX Toulouse HB | 1 |
| 6 | Istres Provence HB | 1 |
Home victories
| 1 | Nantes HBC | 3 |
| 2 | Chambéry Savoie Mt-. | 2 |
| 3 | Cesson Rennes Métro. | 1 |
| 4 | Istres Provence HB | 1 |
| 5 | US Créteil HB | 1 |
| 6 | Chartres Métropole . | 0 |
Tie games at home
| 1 | Cesson Rennes Métro. | 0 |
| 2 | Chambéry Savoie Mt-. | 0 |
| 3 | Chartres Métropole . | 0 |
| 4 | Dunkerque HB Grand Littora. | 0 |
| 5 | FENIX Toulouse HB | 0 |
| 6 | Istres Provence HB | 0 |
Losses at home
| 1 | Cesson Rennes Métro. | 1 |
| 2 | Dunkerque HB Grand Littora. | 1 |
| 3 | FENIX Toulouse HB | 1 |
| 4 | Istres Provence HB | 1 |
| 5 | Limoges Handball | 1 |
| 6 | Saint-Raphaël Var HB | 1 |
Away victories
| 1 | Chambéry Savoie Mt-. | 1 |
| 2 | FENIX Toulouse HB | 1 |
| 3 | Montpellier HB | 1 |
| 4 | Nantes HBC | 1 |
| 5 | Paris SG Handball | 1 |
| 6 | Provence Aix Universit&eac. | 1 |
Tie games: away
| 1 | Cesson Rennes Métro. | 0 |
| 2 | Chambéry Savoie Mt-. | 0 |
| 3 | Chartres Métropole . | 0 |
| 4 | Dunkerque HB Grand Littora. | 0 |
| 5 | FENIX Toulouse HB | 0 |
| 6 | Istres Provence HB | 0 |
Losses: Away
| 1 | Chambéry Savoie Mt-. | 1 |
| 2 | Chartres Métropole . | 1 |
| 3 | Montpellier HB | 1 |
| 4 | Nancy Handball | 1 |
| 5 | Paris SG Handball | 1 |
| 6 | Provence Aix Universit&eac. | 1 |
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