13 October 2021 |
| 18h00 | KP Brno (CZE) | 49 - 55
(21-16, 9-20, 12-12, 7-7) |  Tarbes Gespe Bigorre (FRA) |
14 October 2021 |
| 21h30 | Haukar Hafnarfjordur (ISL) | 41 - 84
(9-26, 11-12, 6-27, 15-19) |  Villeneuve d'Ascq - Lille Metropole (FRA) |
20 October 2021 |
| 20h00 | Villeneuve d'Ascq - Lille Metropole (FRA) | 82 - 42
(11-8, 24-12, 17-9, 30-13) | KP Brno (CZE) |
| 20h00 | Tarbes Gespe Bigorre (FRA) | 66 - 53
(21-11, 10-17, 23-12, 12-13) | Haukar Hafnarfjordur (ISL) |
27 October 2021 |
| 20h00 | Tarbes Gespe Bigorre (FRA) | 78 - 69 ot
(16-14, 9-18, 16-10, 17-16) | Villeneuve d'Ascq - Lille Metropole (FRA) |
28 October 2021 |
| 21h30 | Haukar Hafnarfjordur (ISL) | 61 - 80
(8-25, 11-20, 21-17, 21-18) | KP Brno (CZE) |
3 November 2021 |
| 20h00 | Villeneuve d'Ascq - Lille Metropole (FRA) | 82 - 33
(15-13, 17-12, 31-4, 19-4) | Haukar Hafnarfjordur (ISL) |
| 20h00 | Tarbes Gespe Bigorre (FRA) | 73 - 56
(22-15, 16-12, 20-14, 15-15) | KP Brno (CZE) |
25 November 2021 |
| 18h00 | KP Brno (CZE) | 45 - 71
(8-12, 10-23, 9-20, 18-16) | Villeneuve d'Ascq - Lille Metropole (FRA) |
| 20h30 | Haukar Hafnarfjordur (ISL) | 41 - 79
(8-24, 15-12, 9-16, 9-27) | Tarbes Gespe Bigorre (FRA) |
1 December 2021 |
| 17h00 | KP Brno (CZE) | 60 - 53
(15-25, 11-4, 18-12, 16-12) | Haukar Hafnarfjordur (ISL) |
| 20h00 | Villeneuve d'Ascq - Lille Metropole (FRA) | 86 - 51
(21-17, 23-10, 19-14, 23-10) | Tarbes Gespe Bigorre (FRA) |
Aix en Provence
Dynamo Moscow